https://github.com/pysam-developers/pysam

Pysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.

bioinformatics htslib ngs python

Last synced: 18 Feb 2026