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awesome-virome

A listing of software, tools and databases useful for virome analysis
https://github.com/shandley/awesome-virome

Last synced: about 19 hours ago
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  • Interactive Dashboard

    • Launch Dashboard - virome/citations.html) | [Explore Publication Impact](https://shandley.github.io/awesome-virome/publication_impact.html) | [Compare Tools](https://shandley.github.io/awesome-virome/comparison.html)
  • Tool Selection Guide

  • Virus and Phage Identification

    • Metagenome Analysis

      • HoloVir - Pipeline for taxonomic classification and gene function assignment. [Perl]
      • VIBRANT - Virus identification by combining boundary detection with annotation. [Python]
      • Cenote-Taker 3 - Hallmark gene discovery, gene annotation, flanking host gene removal. [Linux/MacOS] [conda] [v0.1.0, 2023]
      • Cenote-Taker 2 - Scans contigs for virus hallmark genes, removes flanking host DNA from prophages, makes annotated genome maps. [conda, pip] [v2.1.5, 2022]
      • CoCoNet - Neural networks for viral contig identification. [pip] [Python]
      • crassus - Snakemake workflow for phage discovery. [conda] [Python]
      • Deep6 - Machine learning based virus identification. [Python]
      • DeepVirFinder - Neural network approach for viral contig identification. [Python]
      • FastViromeExplorer - Detects viral sequences and predicts abundance by pseudoalignment of reads to a database. [Java]
      • hecatomb - Pipeline for virus identification from metagenomic data. [Nextflow]
      • HoloVir - Pipeline for taxonomic classification and gene function assignment. [Perl]
      • Cenote-Taker 3 - Hallmark gene discovery, gene annotation, flanking host gene removal. [Linux/MacOS] [conda] [v0.1.0, 2023]
      • crassus - Snakemake workflow for phage discovery. [conda] [Python]
      • Cenote-Taker 2 - Scans contigs for virus hallmark genes, removes flanking host DNA from prophages, makes annotated genome maps. [conda, pip] [v2.1.5, 2022]
      • CoCoNet - Neural networks for viral contig identification. [pip] [Python]
      • Deep6 - Machine learning based virus identification. [Python]
      • DePhT - Deep-learning Phage Taxonomy for phage identification. [conda] [Python]
      • FastViromeExplorer - Detects viral sequences and predicts abundance by pseudoalignment of reads to a database. [Java]
      • GenomePeek - Taxonomic classification of multiple domains. [Python]
      • hecatomb - Pipeline for virus identification from metagenomic data. [Nextflow]
      • HoloVir - Pipeline for taxonomic classification and gene function assignment. [Perl]
      • INHERIT - BERT embedding-based phage identification. [Python]
      • INSaFLU-TELEVIR - Platform for virus identification and characterization. [Python]
      • isling - Split read alignment for virus identification. [Python]
      • Jaeger - Phage identification in metagenomes. [Python]
      • Jovian - Public health toolkit focused on human viruses. [Nextflow]
      • LazyPipe - Taxonomic profiling and reference-based detection. [Nextflow]
      • MARVEL - Random forest classifier for phage identification (not for prophages). [Python]
      • metaPhage - Pipeline for phage and virus identification. [conda] [Nextflow]
      • MetaPhinder - Integrates BLAST hits to multiple phage genomes to identify phage sequences. [Python]
      • MetaPhlAn 4.1.0 - Read mapping-based virus identification. [conda, pip] [Python]
      • PhaBox - Integrates several phage tools: PhaMer, PhaTYP, PhaGCN, and CHERRY. [conda] [Python]
      • Phage tools - Collection of tools for predicting and identifying phage in metagenomes. [Python]
      • INHERIT - BERT embedding-based phage identification. [Python]
      • isling - Split read alignment for virus identification. [Python]
      • Jaeger - Phage identification in metagenomes. [Python]
      • Jovian - Public health toolkit focused on human viruses. [Nextflow]
      • MetaPhinder - Integrates BLAST hits to multiple phage genomes to identify phage sequences. [Python]
      • LazyPipe - Taxonomic profiling and reference-based detection. [Nextflow]
      • MARVEL - Random forest classifier for phage identification (not for prophages). [Python]
      • metaPhage - Pipeline for phage and virus identification. [conda] [Nextflow]
      • virAnnot - Pipeline for OTU assignment in viral sequences. [source] [Python]
      • VirFinder - Neural network and machine learning for virus identification. [R]
      • Virhunter - Deep learning approach for virus identification. [Python]
      • PHAMB - Random forest based phage identification. [conda] [Python]
      • MetaPhlAn 4.1.0 - Read mapping-based virus identification. [conda, pip] [Python]
      • PhaBox - Integrates several phage tools: PhaMer, PhaTYP, PhaGCN, and CHERRY. [conda] [Python]
      • Phage tools - Collection of tools for predicting and identifying phage in metagenomes. [Python]
      • PHAMB - Random forest based phage identification. [conda] [Python]
      • phaMers - K-mer and machine learning phage identification. [Python]
      • phaMers - K-mer and machine learning phage identification. [Python]
      • Phanta - K-mer read based classification via snakemake workflow. [yaml] [Python]
      • Phanta - K-mer read based classification via snakemake workflow. [yaml] [Python]
      • Seeker - LSTM-based phage identification (not recommended for prophages). [pip] [Python]
      • PIGv - Giant virus identification using Metabat binning, k-mer scoring, and marker genes. [source] [Python]
      • PPR-Meta - Convolutional neural network for phage prediction. [Python]
      • Prophage Tracer - Split read alignment for prophage identification. [Python]
      • VFM - Virus finder in metagenomic data. [Python]
      • Seeker - LSTM-based phage identification (not recommended for prophages). [pip] [Python]
      • Serratus - Website for virus discovery from public sequencing data. [cloud platform]
      • VIGA - Viral genome assembler. [pip] [Python]
      • VIP - Integrated pipeline for virus identification. [Python]
      • ViralCC - Viral sequence identification via machine learning. [Python]
      • VIP - Integrated pipeline for virus identification. [Python]
      • ViralCC - Viral sequence identification via machine learning. [Python]
      • Serratus - Website for virus discovery from public sequencing data. [cloud platform]
      • ViralConsensus - Viral consensus sequence calling from sequencing data. [source] [Python]
      • VFM - Virus finder in metagenomic data. [Python]
      • VIBRANT - Virus identification by combining boundary detection with annotation. [Python]
      • VIGA - Viral genome assembler. [pip] [Python]
      • ViralConsensus - Viral consensus sequence calling from sequencing data. [source] [Python]
      • viralMetagenomicsPipeline - Snakemake workflow combining virSorter and VirFinder. [Python]
      • ViralWasm - WebAssembly tools for virus identification in the browser. [JavaScript]
      • viralMetagenomicsPipeline - Snakemake workflow combining virSorter and VirFinder. [Python]
      • ViralWasm - WebAssembly tools for virus identification in the browser. [JavaScript]
      • VirFinder - Neural network and machine learning for virus identification. [R]
      • Virhunter - Deep learning approach for virus identification. [Python]
      • virMiner - Random forest approach for virus identification. [R]
      • VirNet - Neural network for phage identification. [Python]
      • ViroProfiler - Comprehensive phage profiling pipeline. [Nextflow]
      • viraMiner - CNN classifier for virus identification. [Python]
      • virAnnot - Pipeline for OTU assignment in viral sequences. [source] [Python]
      • VirSorter2 - Random forest classifier for virus detection. [conda] [Python] [v2.2.4, 2023]
      • Virtifier - LSTM neural network for virus identification. [Python]
      • Virtus - Virus sequence detection workflow. [Snakemake]
      • virus_prediction - Nextflow pipeline with virSorter. [Nextflow]
      • ViruSpy - Virus detection pipeline. [Python]
      • VirMine - Pipeline for virus identification. [Perl]
      • virMiner - Random forest approach for virus identification. [R]
      • VirNet - Neural network for phage identification. [Python]
      • ViroProfiler - Comprehensive phage profiling pipeline. [Nextflow]
      • VirSorter - Detection of viral sequences from microbial genomic data. [bioconda] [Perl] [legacy]
      • VirSorter2 - Random forest classifier for virus detection. [conda] [Python] [v2.2.4, 2023]
      • Virtifier - LSTM neural network for virus identification. [Python]
      • Virtus - Virus sequence detection workflow. [Snakemake]
      • virus_prediction - Nextflow pipeline with virSorter. [Nextflow]
      • ViruSpy - Virus detection pipeline. [Python]
      • VirusSeeker - Pipeline for virus detection from sequence data. [source] [Perl]
      • vRhyme - Machine learning for viral binning from metagenomes. [conda] [Python]
      • What_the_phage - Nextflow workflow combining multiple phage identification tools. [Nextflow]
      • VirusSeeker - Pipeline for virus detection from sequence data. [source] [Perl]
      • vRhyme - Machine learning for viral binning from metagenomes. [conda] [Python]
      • What_the_phage - Nextflow workflow combining multiple phage identification tools. [Nextflow]
    • Integrated Viruses

      • hafeZ - Readmapping approach for integrated phage identification. [Python]
      • LysoPhD - Phage identification tool (code not available).
      • phage_finder - Pipeline for prophage identification. [Perl] [legacy]
      • phageboost - Machine learning with boost algorithm for prophage detection. [R]
      • PhageWeb - Web server for phage identification (API available). [web service]
      • DRAD - Dinucleotide Relative Abundance difference method (no longer available).
      • PHASTER - Rapid identification and annotation of prophage sequences (web service only). [web service]
      • Phigaro - Prophage prediction tool. (Note: downloads uncompressed file from Russian server). [Python]
      • DRAD - Dinucleotide Relative Abundance difference method (no longer available).
      • hafeZ - Readmapping approach for integrated phage identification. [Python]
      • LysoPhD - Phage identification tool (code not available).
      • Prophet - Prophage prediction tool. (Note: requires unsupported legacy software). [Perl] [legacy]
      • Prophinder - Web-based prophage detection tool. [web service]
      • VAPiD - Virus genome annotation and identification tool. [pip] [Python]
      • viralintegration - Nextflow pipeline for detecting viral integration sites. [conda] [Nextflow]
      • geNomad - Tool for identifying viral sequences, including proviruses. [conda] [Python] [v1.6.0, 2023]
      • geNomad - Tool for identifying viral sequences, including proviruses. [conda] [Python] [v1.6.0, 2023]
    • RNA Virus Identification

      • RdRp-scan - Search against the RdRp database. [source] [Python]
      • rdrpsearch - Iterative HMM search of viral RdRp to detect distant homologs. [source] [Python]
      • RNA-Virus-Flow - Pipeline for RNA virus assembly and analysis. [Nextflow]
      • palmID - RNA virus RdRp search tool with R interface. [source, R] [R]
  • Tool Comparison Matrix

  • Acknowledgments

  • Top Packages by Category

  • Host Prediction

    • RNA Virus Identification

      • BacteriophageHostPrediction - Computational methods for phage-host prediction. [Python]
      • CrisprOpenDB - CRISPR spacer database for phage-host prediction. [Python]
      • DeePaC - CNN, ResNet for detection of novel human pathogens. [conda, pip] [Python]
      • DeePaC-Live - DeePaC plugin for real-time analysis during sequencing. [conda, pip] [Python]
      • HostG - Graph convolutional network for phage host prediction. [Python] [v1.0, 2022]
      • HostPhinder - K-mer based phage host prediction. [Python]
      • INFH-VH - Integrating different features for virus-host prediction. [Python]
      • iPHoP - Integrated approach for phage host prediction (formerly iPHoP). Documentation at [iphop.readthedocs.io](https://iphop.readthedocs.io/). [Python] [v1.1.0, 2023]
      • MVP - Microbe-virus database with prediction tools. [web service]
      • PB-LKS - K-mer profiles for phage-bacteria prediction. [Python]
      • PhageHostLearn - Machine learning for phage-host prediction. [Python]
      • PhageRBPdetect - HMMs & machine learning for receptor-binding protein detection. [Python]
      • PHISDetector - Phage-host interaction detection. [web service]
      • PHIST - K-mer based phage-host prediction. [source] [C++]
      • PHP - Phage host prediction tool. [Python]
      • PHERI - Phage-host interaction prediction tool. [Python]
      • PHIAF - GAN-based phage-host interaction prediction. [Python]
      • PHPGCA - Similarity graphs for phage-host prediction. [Python]
      • PredPHI - Phage-host interaction prediction. [Python]
      • RaFaH - Random Forest approach for phage host prediction. [Python]
      • vHulk - Virus host prediction tool. [Python]
      • VIDHOP - Deep learning for virus-host prediction. [conda] [Python]
      • VirHostMatcher - Oligonucleotide frequency-based host prediction. [Python]
      • VirHostMatcher-Net - Network-based virus-host prediction. [Python]
      • VirMatcher - Multiple methods for phage host prediction with confidence scores. [conda] [Python] [v1.0, 2022]
      • Virus Host DB - Database for virus-host relationships. [web service]
      • Virus Host Predict - Host prediction for viral sequences. [Python]
      • WIsH - Phage-host prediction using genome homology. [C++]
  • Genome Analysis

    • Genome Annotation

      • DRAMv - Distilling and refining annotation of metabolism for phages. [conda, pip] [Python] [v1.4.6, 2023]
      • MetaCerberus - HMM-based annotation with Ray MPP. [conda, pip] [Python]
      • PhANNs - Phage annotation neural networks. (Python version available via contact) [Python]
    • Genome Assembly

      • metaviralSPAdes - Assembler for viruses from metagenomic data. [C++]
      • VEGA - Snakemake workflow for viral genome assembly. [conda] [Snakemake]
    • Genome Completeness

      • CheckV - Quality assessment for viral genomes. (Not recommended for prophages) [conda, pip] [Python] [v1.0.1, 2022]
      • viralComplete - Tool for checking viral genome completeness. [Python]
      • viralVerify - Verification of viral contigs. [Python]
    • Genome Comparison

      • mulitPHATE - Multi-phage annotation and comparison tool. [Python]
      • PhageClouds - Network graphs for phage comparison (website down, source code not found).
    • Gene Finding

      • PhiSpy - While primarily for prophage identification, includes ORF prediction capabilities. [conda, pip] [Python]
      • GLIMMER - Gene finder originally designed for bacteria but frequently used for phage genomes. [source] [C++]
      • VIGOR - Viral genome annotation tool designed specifically for viral genomes, primarily eukaryotic viruses. [source] [Java/Perl]
      • PhageTerm - Tool for identifying phage termini and packaging mechanisms, helpful for ORF identification. [source] [Python]
      • GeneMarkS - Gene prediction tool with specific models for viral sequences. [web service] [Perl/C++]
      • GeneMarkS-2 - Improved version of GeneMarkS with enhanced performance for phage genomes. [web service] [Perl/C++]
      • PhageBoost - Machine learning tool for identifying structural proteins in phage genomes. [R]
      • VGAS - Comprehensive pipeline for viral genome annotation including gene finding. [source] [Python]
  • Taxonomy

    • Gene Finding

      • BERTax - BERT-based viral taxonomy tool. [Python]
      • Classiphages 2.0 - Artificial neural network for phage classification (code not available).
      • GraViTy - HMMs and genome organization models for virus taxonomy. [R]
      • VIPtree - Viral proteomic tree generation tool. [Perl]
      • VIRIDIC - Virus intergenomic distance calculator. [R]
      • VIRify - Nextflow pipeline for viral taxonomy. [Nextflow]
      • VirusTaxo - K-mer enrichment method for viral taxonomy. [source] [Python]
      • VPF Tools - Viral protein family analysis tools. [Python]
      • PhaGCN - Graph convolutional network for phage taxonomy. [Python] [v1.0, 2022]
      • vConTACT - Whole-genome gene-sharing networks for virus taxonomy. [Python] [legacy]
      • vConTACT2.0 - Updated version of vConTACT with improved performance. [Python] [v0.9.19, 2023]
      • VICTOR - Genome-based phylogeny and classification of phages. [web service]
  • Databases

    • Gene Finding

      • FDA ARGOS - Curated database of reference genomes of microbial sequences, for diagnostic use. [web service] [Updated 2023]
      • ICTV Virus Metadata Resource (VMR) - Curated database of sequences of exemplars for each classified virus species. [Updated 2023]
      • NCBI RefSeq - Curated database of annotated genomic, transcript, and protein sequence records: viruses (ca. 8500 complete viral genomes), prokaryotes, eukaryotes. [Updated 2023]
      • NCBI GenBank - Uncurated database of all publicly available nucleotide sequences, annotated. [Updated 2023]
      • Reference Viral DataBase (RVDB), nucleic version - Curated database of virus nucleotide sequences, available as Unclustered (U-) and Clustered (C-) nucleotide sequence files. [Updated 2023]
      • Reference Viral DataBase (RVDB), protein version - Protein version (RVDB-prot and RVDB-prot-HMM) of the curated U-RVDB described above. [Updated 2023]
      • SIB Viral reference sequences - Curated database of annotated viral genomes generated by the Swiss Institute of Bioinformatics (SIB). [Updated 2023]
      • UniProt Virus proteomes - Curated and annotated database of proteomic virus references (ca. 10,000 virus reference proteomes). [Updated 2023]
      • VirMet - In-house database download from GenBank of viral references. [Python]
      • Virosaurus - Curated database of virus sequences for clinical metagenomics, clustered (non-redundant). [Updated 2022]
      • Virion - An open database of vertebrate-virus interactions. [R]
  • Sequence Databases

    • Gene Finding

      • CHVD - Comprehensive human virus database. [2021]
      • Earth Virome - Collection of viral sequences from environmental samples. [2021]
      • GOV-RNA - Global Ocean RNA viruses sequence database. [2021]
      • GOV2.0 - Global Ocean DNA viruses sequence database. [2021]
      • GPDB - Gut phage database. [2021]
      • GVD - Global virome database. [2020]
      • KEGG Virus - KEGG collection of virus genomes. [Updated 2023]
      • mMGE - Mobile genetic element database. [Updated 2023]
      • PhagesDB - Database of phage genomes. [Updated 2023]
      • ViromeDB - Public collection of >162,000 viral sequences. [2019]
      • Viruses.String - Virus-host protein-protein interactions database. [Updated 2022]
  • Functional Analysis

    • Evolutionary Analysis

      • OLGenie - Program for estimating dN/dS in overlapping genes. [source, Perl] [Perl]
      • SNPGenie - Program for estimating πN/πS and diversity measures. [conda, Perl] [Perl]
      • VCFgenie - Program for filtering VCF files and eliminating false positive variants. [source, Python] [Python]
      • VIPERA - Phylogenetic and population genetics analysis of intra-patient SARS-CoV-2. [source] [R]
    • Lifestyle Classification

      • PhageAI - NLP, ML for phage lifestyle classification. [pip] [Python]
      • BACPHLIP - Random Forest classifier for phage lifestyle. [conda, pip] [Python] [v0.9.6, 2023]
      • PHACTS - Phage classification tool suite. [Python]
    • Phage-specific Analysis

      • PHROGs - Phage-specific orthologous groups. [Database, 2021]
      • PHRED - Phage receptor identification tool (no longer available).
      • SpikeHunter - Phage tail spike identification using protein embeddings. [Python]
    • Viral Orthologous Groups

      • efam - Expanded metaproteome-supported HMM profile database of viral protein families. [2020]
      • pVOGs - Prokaryotic virus orthologous groups. [Database]
      • VogDB - Virus orthologous groups database. [Database, Updated 2023]
  • CRISPR Analysis

    • Viral Orthologous Groups

      • MaGplotR - CRISPR screen visualization tool. [R]
      • SpacePHARER - CRISPR spacer phage-host pair finder. [C++]
  • Sequence Analysis

    • Multiple Sequence Alignment

      • ViralMSA - Python script for viral multiple sequence alignment using read mappers. [source] [Python]
    • Sequence Translation

      • pygenetic_code - C and Python tools for genetic code translation. [conda, pip] [Python]
  • Visualization and Infrastructure

    • Cyberinfrastructure

      • BVBRC - BV-BRC website for virus bioinformatics. [web service]
      • iVirus 2.0 - Integrated iVirus apps on CyVerse and KBase. [web service]
    • Plaque Analysis

  • Other Tools

    • Simulation

      • FAVITES - Simulate contact networks, transmission, phylogenies, and sequences. [source] [Python]
      • FAVITES-Lite - Lighter version of FAVITES. [source] [Python]
    • Quality Control

      • ViromeQC - Virome quality control and contamination assessment. [source] [Python]
    • Amplicon Analysis

      • vAMPirus - Nextflow pipeline for virus amplicon processing and analysis. [conda] [Nextflow]
    • Viral Strain Reconstruction

      • COBRA - Viral strain reconstruction using contig overlaps. [Python]
      • Phables - Flow decomposition on assembly graphs for phage strain reconstruction. [conda, pip] [Python]
      • VStrains - Viral strain reconstruction from metagenomic data. [Python]
    • Transduction

      • TrIdent - Transduction identification via read coverage pattern matching. [R]
    • Interaction Analysis

      • DeepVHPPI - Deep learning for virus-host protein-protein interactions. [Python]
      • DePP - Depolymerase finder for phages. [web service]
      • PhageDPO - SVM and ANN for phage depolymerase prediction. [Python]
      • PhageTB - BLAST-based phage therapy tools. [Python]
      • PhageTerm - Predicting phage packaging mechanism. [source] [Python]
      • PhagePromoter - ANN, SVM for phage promoter prediction. [source] [Python]
      • VIRMOTIF - Tool for identifying viral genome motifs. [Python]
    • Antimicrobial Resistance Analysis

      • AMRFinder - NCBI's tool for identifying resistance genes, can be applied to phage genomes. [C++]
      • PHANOTATE-AMR - Extension adding AMR gene identification in phages. [Python]
      • ResFinder - Identifies resistance genes in bacteriophages. [Python]
      • VirAMR - Detects antimicrobial resistance genes in viral genomes. [Python]
    • Structural Analysis Tools

      • HNADOCK - Modeling of nucleic acid-protein complexes, useful for viral proteins. [web service]
      • I-TASSER - Widely used for viral protein structure prediction. [web service]
      • VIPERdb - Virus particle explorer database with structure visualization. [web service]
      • VIRALpro - Viral capsid and tail protein prediction. [web service]
    • Viral Metatranscriptomics

      • VirMine-RNA - Focused on detecting RNA viruses in transcriptomic data. [Python]
      • VirusTAP - Transcriptome Assembler Pipeline for viral sequence discovery. [Perl]
    • Viral Quasispecies Analysis

      • CliqueSNV - Reconstruction of virus haplotypes in a mixed population. [Java]
      • QuRe - Viral quasispecies reconstruction tool. [Java]
      • ShoRAH - Short reads assembly into haplotypes for viral population. [C++]
      • V-pipe - Pipeline for viral population analysis. [Nextflow]
      • ViQuaS - Viral Quasispecies reconstruction. [Python]
    • Cloud-based Viral Analysis

      • CloVR-Microbe - Cloud-based viral metagenomics pipeline. [Perl]
      • Viral Beacon - Cloud platform for virus sequence sharing and analysis. [Python]
      • Viral-NGS - Broad Institute's viral genomic analysis on cloud. [Python]
    • Machine Learning Models

    • Viral Single-Cell Analysis

      • scViroCap - Single-cell viral capture sequencing analysis. [Python]
      • scVIRseq - Single-cell virus infection profiling. [Python]
      • Viral-Track - Tracking viruses in single-cell RNA-Seq data. [R]
      • MAVERIC - Analyzing viral infections at the single-cell level. [Python]
    • Viral Glycoprotein Analysis

      • GlycoProtViz - Visualizing viral glycoprotein structures. [Python]
      • GlyConnect - Database with viral glycosylation data. [web service]
      • NetNGlyc - N-glycosylation site prediction in viral proteins. [web service]
      • pGlyco - Glycopeptide identification in viral proteins. [C++]
    • Ancient Viral Sequence Analysis

      • EVE - Ancient viral element detection in genomes. [Python]
      • HOPS - Pathogen screening for ancient DNA, includes viral sequences. [Java]
      • Paleovirology - Tools for detecting ancient viral elements. [Perl]
      • PastML - Useful for ancient viral sequence reconstruction. [Python]
    • Viral Immune Epitope Prediction

      • EpiDOCK - Viral epitope docking and analysis. [web service]
      • IEDB-tools - Suite of tools for epitope prediction. [Python]
      • NetMHCpan - Neural network for MHC binding prediction in viral proteins. [web service]
      • TepiTool - T-cell epitope prediction for viral sequences. [web service]
    • Viral Molecular Dynamics

      • CHARMM-GUI - Web-based interface for viral particle simulation setup. [web service]
      • CovidMD - COVID-19 specific molecular dynamics toolbox (extensible to other viruses). [C++]
      • NAMD-VIRAL - Molecular dynamics simulations of viral proteins. [C++]
      • VMD-Viral - Visualization of viral molecular dynamics. [C++]
    • Dark Matter Viral Analysis