Admin Panels

• Ajenti - The admin panel your servers deserve.
• flower - Real-time monitor and web admin for Celery.
• Wooey - A Django app which creates automatic web UIs for Python scripts.

Algorithms and Design Patterns

• PyPattyrn - A simple yet effective library for implementing common design patterns.
• python-patterns - A collection of design patterns in Python.

Anti-spam

• django-simple-captcha - A simple and highly customizable Django app to add captcha images to any Django form.

Asset Management

• django-storages - A collection of custom storage back ends for Django.

Audio

• audioread - Cross-library (GStreamer + Core Audio + MAD + FFmpeg) audio decoding.
• m3u8 - A module for parsing m3u8 file.
• mutagen - A Python module to handle audio metadata.
• pyAudioAnalysis - Python Audio Analysis Library: Feature Extraction, Classification, Segmentation and Applications
• TimeSide - Open web audio processing framework.
• tinytag - A library for reading music meta data of MP3, OGG, FLAC and Wave files.

Authentication

• Authomatic - Simple but powerful framework agnostic authentication/authorization client.
• django-allauth - Authentication app for Django that "just works."
• Flask-OAuthlib - OAuth 1.0/a, 2.0 implementation of client and provider for Flask.
• PyJWT - Implementation of the JSON Web Token draft 01.

Build Tools

• PyBuilder - A continuous build tool written in pure Python.

Caching

• django-cacheops - A slick ORM cache with automatic granular event-driven invalidation.

Command-line Tools

• asciimatics - Cross-platform, full-screen terminal package (i.e. mouse/keyboard input and coloured, positioned text output) complete with high-level API for complex animations and special effects.
• Python-Fire - A library for creating command line interfaces (CLIs) from absolutely any Python object.
• doitlive - A tool for live presentations in the terminal.
• httpie - A command line HTTP client, a user-friendly cURL replacement.
• mycli - A Terminal Client for MySQL with AutoCompletion and Syntax Highlighting.
• pgcli - Postgres CLI with autocompletion and syntax highlighting.
• SAWS - A Supercharged AWS CLI.
• thefuck - Correcting your previous console command.
• try - A dead simple CLI to try out python packages - It's never been easier.

Computer Vision

• pyocr - A wrapper for Tesseract and Cuneiform.

Concurrency and Parallelism

• uvloop - Ultra fast implementation of asyncio event loop on top of libuv.

Cryptography

• PyNacl - Python binding to the Networking and Cryptography (NaCl) library.

Data Analysis

• Open Mining - Business Intelligence (BI) in Pandas interface.

Database

• TinyDB - A tiny, document-oriented database.

Database Drivers

• PyMySQL - Pure Python MySQL driver compatible to mysql-python.
• dataset - Store Python dicts in a database - works with SQLite, MySQL, and PostgreSQL.

Data Validation

• Cerberus - A lightweight and extensible data validation library.
• Schematics - Data Structure Validation.

Data Visualization

• Bokeh - Interactive Web Plotting for Python.
• Seaborn - Statistical data visualization using Matplotlib.
• VisPy - High-performance scientific visualization based on OpenGL.

Date and Time

• dateutil - Extensions to the standard Python datetime module.
• PyTime - A easy-use Python module which aims to operate date/time/datetime by string.
• maya - Datetimes for Humans, Maya is mostly built around the headaches and use-cases around parsing datetime data from websites.

Debugging Tools

• remote-pdb - Remote vanilla PDB (over TCP sockets).
• profiling - An interactive Python profiler.
• vprof - Visual Python profiler.
• hunter - Hunter is a flexible code tracing toolkit.
• manhole - Debug service that will accept unix domain socket connections and present the stacktraces for all threads and an interactive prompt.
• pyelftools - Parsing and analyzing ELF files and DWARF debugging information.

Deep Learning

• Serpent.AI - Game agent framework. Use any video game as a deep learning sandbox.
• TensorFlow - The most popular Deep Learning framework created by Google.

DevOps Tools

• Ansible - A radically simple IT automation platform.
• Fabtools - Tools for writing awesome Fabric files.
• honcho - A Python clone of Foreman, for managing Procfile-based applications.
• psutil - A cross-platform process and system utilities module.
• SaltStack - Infrastructure automation and management system.

Distribution

• dh-virtualenv - Build and distribute a virtualenv as a Debian package.
• PyInstaller - Converts Python programs into stand-alone executables (cross-platform).

Documentation

• awesome-sphinxdoc

Downloader

• s3cmd - A command line tool for managing Amazon S3 and CloudFront.
• s4cmd - Super S3 command line tool, good for higher performance.

E-commerce

• forex-python - Foreign exchange rates, Bitcoin price index and currency conversion.

Editor Plugins and IDEs

• Anaconda - Anaconda turns your Sublime Text 3 in a full featured Python development IDE.
• Python - An extension with rich support for the Python language, with features including linting, IntelliSense, formatting, refactoring, debugging, unit tests, and jupyter support.
• Magic Python - Cutting edge Python syntax highlighter for Sublime Text, Atom, and Visual Studio Code. Used by GitHub to highlight your Python code!
• Spyder - Open Source Python IDE.

Email

• imbox - Python IMAP for Humans.
• Marrow Mailer - High-performance extensible mail delivery framework.
• yagmail - Yet another Gmail/SMTP client.

Environment Management

• pyenv - Simple Python version management.

Forms

• Deform - Python HTML form generation library influenced by the formish form generation library.

Functional Programming

• funcy - A fancy and practical functional tools.

Geolocation

• django-countries - A Django app that provides country choices for use with forms, flag icons static files, and a country field for models.
• geopy - Python Geocoding Toolbox.

GUI

• enaml - Creating beautiful user-interfaces with Declaratic Syntax like QML.

Hardware

• keyboard - Hook and simulate global keyboard events on Windows and Linux.
• scapy - A brilliant packet manipulation library.
• wifi - A Python library and command line tool for working with WiFi on Linux.

HTML Manipulation

• MarkupSafe - Implements a XML/HTML/XHTML Markup safe string for Python.
• pyquery - A jQuery-like library for parsing HTML.
• untangle - Converts XML documents to Python objects for easy access.

HTTP

• httplib2 - Comprehensive HTTP client library.
• treq - Python requests like API built on top of Twisted's HTTP client.

Imagery

• pillow - Pillow is the friendly PIL fork.

Implementations

• CLPython - Implementation of the Python programming language written in Common Lisp.
• IronPython - Implementation of the Python programming language written in C# targeting the .NET Framework and Mono.
• MicroPython - MicroPython - a lean and efficient Python programming language implementation for microcontrollers and constrained systems
• PeachPy - x86-64 assembler embedded in Python. Can be used as inline assembler for Python or as a stand-alone assembler for Windows, Linux, OS X, Native Client and Go.

Job Scheduler

• Spiff - A powerful workflow engine implemented in pure Python.

Logging

• raven - Python client for Sentry, a log/error tracking, crash reporting and aggregation platform for web applications.

MapReduce

• luigi - A module that helps you build complex pipelines of batch jobs.

Microsoft Windows

• PythonNet - Python Integration with the .NET Common Language Runtime (CLR).

Miscellaneous

• attrs - Replacement for __init__, __eq__, __repr__, etc. boilerplate in class definitions.
• itsdangerous - Various helpers to pass trusted data to untrusted environments.
• Pychievements - A framework for creating and tracking achievements.

Natural Language Processing

• TextBlob - Providing a consistent API for diving into common NLP tasks.

Networking

• pulsar - Event-driven concurrent framework for Python.
• txZMQ - Twisted based wrapper for the ZeroMQ message library.

ORM

• awesome-sqlalchemy
• Peewee - A small, expressive ORM.
• flywheel - Object mapper for Amazon DynamoDB.
• PynamoDB - A Pythonic interface for Amazon DynamoDB.

Package Management

• pip-tools - A set of tools to keep your pinned Python dependencies fresh.

Package Repositories

• warehouse - Next generation Python Package Repository (PyPI).

Permissions

• django-rules - A tiny but powerful app providing object-level permissions to Django, without requiring a database.

Processes

• sh - A full-fledged subprocess replacement for Python.

Queue

• huey - Little multi-threaded task queue.

Recommender Systems

• annoy - Approximate Nearest Neighbors in C++/Python optimized for memory usage.
• LightFM - A Python implementation of a number of popular recommendation algorithms.
• TensorRec - A Recommendation Engine Framework in TensorFlow.

RESTful API

• eve - REST API framework powered by Flask, MongoDB and good intentions.
• hug - A Python3 framework for cleanly exposing APIs over HTTP and the Command Line with automatic documentation and validation.
• restless - Framework agnostic REST framework based on lessons learned from Tastypie.
• apistar - A smart Web API framework, designed for Python 3.

Science

• statsmodels - Statistical modeling and econometrics in Python.
• SymPy - A Python library for symbolic mathematics.
• Zipline - A Pythonic algorithmic trading library.

Search

• elasticsearch-dsl-py - The official high-level Python client for Elasticsearch.
• pysolr - A lightweight Python wrapper for Apache Solr (incl. SolrCloud awareness).

Serialization

• marshmallow - marshmallow is an ORM/ODM/framework-agnostic library for converting complex datatypes, such as objects, to and from native Python datatypes.

Serverless Frameworks

• python-lambda - A toolkit for developing and deploying Python code in AWS Lambda.
• Zappa - A tool for deploying WSGI applications on AWS Lambda and API Gateway.

Specific Formats Processing

• pyexcel - Providing one API for reading, manipulating and writing csv, ods, xls, xlsx and xlsm files.
• PyPDF2 - A library capable of splitting, merging and transforming PDF pages.
• Python-Markdown - A Python implementation of John Gruber’s Markdown.

Template Engine

• Jinja2 - A modern and designer friendly templating language.

Testing

• nose2 - The successor to nose, based on unittest2.
• Robot Framework - A generic test automation framework.
• green - A clean, colorful test runner.
• locust - Scalable user load testing tool written in Python.
• splinter - Open source tool for testing web applications.
• httmock - A mocking library for requests for Python 2.6+ and 3.2+.
• httpretty - HTTP request mock tool for Python.
• Mocket - Socket Mock Framework plus HTTP[S]/asyncio/gevent mocking library with recording/replaying capability.
• VCR.py - Record and replay HTTP interactions on your tests.
• factory_boy - A test fixtures replacement for Python.
• mimesis - is a Python library that help you generate fake data.
• fake2db - Fake database generator.
• faker - A Python package that generates fake data.

Text Processing

• pangu.py - Spacing texts for CJK and alphanumerics.
• pyfiglet - An implementation of figlet written in Python.
• pypinyin - Convert Chinese hanzi to pinyin.
• python-nameparser - Parsing human names into their individual components.
• python-user-agents - Browser user agent parser.
• sqlparse - A non-validating SQL parser.

Third-party APIs

• boto3 - Python interface to Amazon Web Services.
• facebook-sdk - Facebook Platform Python SDK.
• facepy - Facepy makes it really easy to interact with Facebook's Graph API

URL Manipulation

• furl - A small Python library that makes parsing and manipulating URLs easy.
• pyshorteners - A pure Python URL shortening lib.

Web Content Extracting

• html2text - Convert HTML to Markdown-formatted text.
• lassie - Web Content Retrieval for Humans.
• micawber - A small library for extracting rich content from URLs.
• newspaper - News extraction, article extraction and content curation in Python.
• opengraph - A Python module to parse the Open Graph Protocol
• sumy - A module for automatic summarization of text documents and HTML pages.
• textract - Extract text from any document, Word, PowerPoint, PDFs, etc.
• toapi - Every web site provides APIs

Web Crawling

• pyspider - A powerful spider system.

Web Frameworks

• awesome-dash
• awesome-flask
• Sanic - Web server that's written to go fast.

WebSocket

• AutobahnPython - WebSocket & WAMP for Python on Twisted and asyncio.
• WebSocket-for-Python - WebSocket client and server library for Python 2 and 3 as well as PyPy.

Weekly

• awesomo
• pycrumbs
• pythonidae