Admin Panels

• ajenti - The admin panel your servers deserve.
• flower - Real-time monitor and web admin for Celery.
• wooey - A Django app which creates automatic web UIs for Python scripts.

Algorithms and Design Patterns

• algorithms - Minimal examples of data structures and algorithms.
• sortedcontainers - Fast and pure-Python implementation of sorted collections.
• TheAlgorithms - All Algorithms implemented in Python.
• PyPattyrn - A simple yet effective library for implementing common design patterns.
• python-patterns - A collection of design patterns in Python.
• transitions - A lightweight, object-oriented finite state machine implementation.

ASGI Servers

• uvicorn - A lightning-fast ASGI server implementation, using uvloop and httptools.

Asynchronous Programming

• awesome-asyncio
• trio - A friendly library for async concurrency and I/O.
• uvloop - Ultra fast asyncio event loop.

Audio

• audioread - Cross-library (GStreamer + Core Audio + MAD + FFmpeg) audio decoding.
• librosa - Python library for audio and music analysis
• matchering - A library for automated reference audio mastering.
• pyAudioAnalysis - Audio feature extraction, classification, segmentation and applications.
• TimeSide - Open web audio processing framework.
• beets - A music library manager and MusicBrainz tagger.
• eyeD3 - A tool for working with audio files, specifically MP3 files containing ID3 metadata.
• mutagen - A Python module to handle audio metadata.
• tinytag - A library for reading music meta data of MP3, OGG, FLAC and Wave files.

Authentication

• django-allauth - Authentication app for Django that "just works."
• pyjwt - JSON Web Token implementation in Python.

Build Tools

• pybuilder - A continuous build tool written in pure Python.

Built-in Classes Enhancement

• attrs - Replacement for __init__, __eq__, __repr__, etc. boilerplate in class definitions.
• bidict - Efficient, Pythonic bidirectional map data structures and related functionality..
• Box - Python dictionaries with advanced dot notation access.

Caching

• django-cacheops - A slick ORM cache with automatic granular event-driven invalidation.

CMS

• indico - A feature-rich event management system, made @ CERN.

Code Analysis

• awesome-python-typing
• vulture - A tool for finding and analysing dead Python code.
• awesome-flake8-extensions
• wemake-python-styleguide - The strictest and most opinionated python linter ever.
• black - The uncompromising Python code formatter.
• yapf - Yet another Python code formatter from Google.
• pyre-check - Performant type checking.
• typeshed - Collection of library stubs for Python, with static types.
• pytype - Pytype checks and infers types for Python code - without requiring type annotations.

Command-line Interface Development

• python-fire - A library for creating command line interfaces from absolutely any Python object.
• alive-progress - A new kind of Progress Bar, with real-time throughput, eta and very cool animations.
• asciimatics - A package to create full-screen text UIs (from interactive forms to ASCII animations).
• tqdm - Fast, extensible progress bar for loops and CLI.

Command-line Tools

• doitlive - A tool for live presentations in the terminal.
• thefuck - Correcting your previous console command.
• try - A dead simple CLI to try out python packages - it's never been easier.
• httpie - A command line HTTP client, a user-friendly cURL replacement.
• kube-shell - An integrated shell for working with the Kubernetes CLI.
• litecli - SQLite CLI with autocompletion and syntax highlighting.
• mycli - MySQL CLI with autocompletion and syntax highlighting.
• pgcli - PostgreSQL CLI with autocompletion and syntax highlighting.
• saws - A Supercharged aws-cli.

Computer Vision

• EasyOCR - Ready-to-use OCR with 40+ languages supported.
• Face Recognition - Simple facial recognition library.
• SimpleCV - An open source framework for building computer vision applications.

Cryptography

• pynacl - Python binding to the Networking and Cryptography (NaCl) library.

Data Analysis

• Open Mining - Business Intelligence (BI) in Pandas interface.

Database

• pickleDB - A simple and lightweight key-value store for Python.
• tinydb - A tiny, document-oriented database.
• ZODB - A native object database for Python. A key-value and object graph database.

Database Drivers

• py2neo - A client library and toolkit for working with Neo4j.
• PyMySQL - A pure Python MySQL driver compatible to mysql-python.
• kafka-python - The Python client for Apache Kafka.
• pymongo - The official Python client for MongoDB.
• motor - The async Python driver for MongoDB.

Data Validation

• Cerberus - A lightweight and extensible data validation library.
• Schematics - Data Structure Validation.

Data Visualization

• Bokeh - Interactive Web Plotting for Python.
• Cartopy - A cartographic python library with matplotlib support
• awesome-dash
• plotnine - A grammar of graphics for Python based on ggplot2.
• Seaborn - Statistical data visualization using Matplotlib.
• VisPy - High-performance scientific visualization based on OpenGL.

Date and Time

• dateutil - Extensions to the standard Python datetime module.
• maya - Datetimes for Humans.
• PyTime - An easy-to-use Python module which aims to operate date/time/datetime by string.

Debugging Tools

• ipdb - IPython-enabled pdb.
• pudb - A full-screen, console-based Python debugger.
• manhole - Debugging UNIX socket connections and present the stacktraces for all threads and an interactive prompt.
• python-hunter - A flexible code tracing toolkit.
• profiling - An interactive Python profiler.
• py-spy - A sampling profiler for Python programs. Written in Rust.
• vprof - Visual Python profiler.
• icecream - Inspect variables, expressions, and program execution with a single, simple function call.
• pyelftools - Parsing and analyzing ELF files and DWARF debugging information.

Deep Learning

• keras - A high-level neural networks library and capable of running on top of either TensorFlow or Theano.
• pytorch - Tensors and Dynamic neural networks in Python with strong GPU acceleration.
• SerpentAI - Game agent framework. Use any video game as a deep learning sandbox.
• tensorflow - The most popular Deep Learning framework created by Google.

DevOps Tools

• ansible - A radically simple IT automation platform.
• pyinfra - A versatile CLI tools and python libraries to automate infrastructure.
• saltstack - Infrastructure automation and management system.
• fabtools - Tools for writing awesome Fabric files.
• honcho - A Python clone of Foreman, for managing Procfile-based applications.
• psutil - A cross-platform process and system utilities module.

Distributed Computing

• dask - A flexible parallel computing library for analytic computing.
• luigi - A module that helps you build complex pipelines of batch jobs.
• faust - A stream processing library, porting the ideas from Kafka Streams to Python.

Distribution

• dh-virtualenv - Build and distribute a virtualenv as a Debian package.
• pyarmor - A tool used to obfuscate python scripts, bind obfuscated scripts to fixed machine or expire obfuscated scripts.
• PyInstaller - Converts Python programs into stand-alone executables (cross-platform).

Documentation

• awesome-sphinxdoc
• pdoc - Epydoc replacement to auto generate API documentation for Python libraries.

Downloader

• s3cmd - A command line tool for managing Amazon S3 and CloudFront.
• s4cmd - Super S3 command line tool, good for higher performance.

E-commerce

• forex-python - Foreign exchange rates, Bitcoin price index and currency conversion.

Editor Plugins and IDEs

• anaconda - Anaconda turns your Sublime Text 3 in a full featured Python development IDE.
• spyder - Open Source Python IDE.

Email

• salmon - A Python Mail Server.
• imbox - Python IMAP for Humans.
• yagmail - Yet another Gmail/SMTP client.
• mailer - High-performance extensible mail delivery framework.

Environment Management

• pyenv - Simple Python version management.
• virtualenv - A tool to create isolated Python environments.

Files

• PyFilesystem2 - Python's filesystem abstraction layer.

Forms

• Deform - Python HTML form generation library influenced by the formish form generation library.
• django-bootstrap4 - Bootstrap 4 integration with Django.

Functional Programming

• Coconut - A variant of Python built for simple, elegant, Pythonic functional programming.
• funcy - A fancy and practical functional tools.
• returns - A set of type-safe monads, tranformers, and composition utilities.

Geolocation

• django-countries - A Django app that provides a country field for models and forms.
• geopy - Python Geocoding Toolbox.

GUI Development

• enaml - Creating beautiful user-interfaces with Declarative Syntax like QML.
• pyglet - A cross-platform windowing and multimedia library for Python.
• PySimpleGUI - Wrapper for tkinter, Qt, WxPython and Remi.

Hardware

• keyboard - Hook and simulate global keyboard events on Windows and Linux.
• scapy - A brilliant packet manipulation library.
• wifi - A Python library and command line tool for working with WiFi on Linux.

HTML Manipulation

• MarkupSafe - Implements a XML/HTML/XHTML Markup safe string for Python.
• pyquery - A jQuery-like library for parsing HTML.
• untangle - Converts XML documents to Python objects for easy access.

HTTP Clients

• httplib2 - Comprehensive HTTP client library.
• httpx - A next generation HTTP client for Python.
• requests - HTTP Requests for Humans.
• treq - Python requests like API built on top of Twisted's HTTP client.

Image Processing

• pillow - Pillow is the friendly PIL fork.
• python-barcode - Create barcodes in Python with no extra dependencies.
• pyvips - A fast image processing library with low memory needs.

Implementations

• CLPython - Implementation of the Python programming language written in Common Lisp.
• IronPython - Implementation of the Python programming language written in C#.
• MicroPython - A lean and efficient Python programming language implementation.
• PeachPy - x86-64 assembler embedded in Python.

Interactive Interpreter

• awesome-jupyter

Job Scheduler

• Prefect - A modern workflow orchestration framework that makes it easy to build, schedule and monitor robust data pipelines.
• Spiff - A powerful workflow engine implemented in pure Python.

Logging

• loguru - Library which aims to bring enjoyable logging in Python.
• sentry-python - Sentry SDK for Python.

Machine Learning

• H2O - Open Source Fast Scalable Machine Learning Platform.

Microsoft Windows

• PythonNet - Python Integration with the .NET Common Language Runtime (CLR).
• PyWin32 - Python Extensions for Windows.

Miscellaneous

• boltons - A set of pure-Python utilities.
• itsdangerous - Various helpers to pass trusted data to untrusted environments.

Natural Language Processing

• pattern - A web mining module.
• PyTorch-NLP - A toolkit enabling rapid deep learning NLP prototyping for research.
• Stanza - The Stanford NLP Group's official Python library, supporting 60+ languages.

Network Virtualization

• mininet - A popular network emulator and API written in Python.

ORM

• awesome-sqlalchemy
• dataset - Store Python dicts in a database - works with SQLite, MySQL, and PostgreSQL.
• orator - The Orator ORM provides a simple yet beautiful ActiveRecord implementation.
• peewee - A small, expressive ORM.
• mongoengine - A Python Object-Document-Mapper for working with MongoDB.
• PynamoDB - A Pythonic interface for Amazon DynamoDB.

Package Management

• pip-tools - A set of tools to keep your pinned Python dependencies fresh.

Package Repositories

• devpi - PyPI server and packaging/testing/release tool.
• warehouse - Next generation Python Package Repository (PyPI).

Penetration Testing

• fsociety - A Penetration testing framework.
• sqlmap - Automatic SQL injection and database takeover tool.

Permissions

• django-rules - A tiny but powerful app providing object-level permissions to Django, without requiring a database.

Processes

• delegator.py - Subprocesses for Humans 2.0.
• sh - A full-fledged subprocess replacement for Python.

Recommender Systems

• annoy - Approximate Nearest Neighbors in C++/Python optimized for memory usage.
• lightfm - A Python implementation of a number of popular recommendation algorithms.
• spotlight - Deep recommender models using PyTorch.
• tensorrec - A Recommendation Engine Framework in TensorFlow.

Refactoring

• Rope - Rope is a python refactoring library.

RESTful API

• eve - REST API framework powered by Flask, MongoDB and good intentions.
• apistar - A smart Web API framework, designed for Python 3.
• falcon - A high-performance framework for building cloud APIs and web app backends.
• hug - A Python 3 framework for cleanly exposing APIs.
• sandman2 - Automated REST APIs for existing database-driven systems.

Robotics

• PythonRobotics - This is a compilation of various robotics algorithms with visualizations.

Science

• statsmodels - Statistical modeling and econometrics in Python.
• SymPy - A Python library for symbolic mathematics.
• Zipline - A Pythonic algorithmic trading library.

Search

• elasticsearch-dsl-py - The official high-level Python client for Elasticsearch.
• pysolr - A lightweight Python wrapper for Apache Solr.

Serialization

• marshmallow - A lightweight library for converting complex objects to and from simple Python datatypes.
• pysimdjson - A Python bindings for simdjson.

Serverless Frameworks

• python-lambda - A toolkit for developing and deploying Python code in AWS Lambda.
• Zappa - A tool for deploying WSGI applications on AWS Lambda and API Gateway.

Specific Formats Processing

• pyexcel - Providing one API for reading, manipulating and writing csv, ods, xls, xlsx and xlsm files.
• XlsxWriter - A Python module for creating Excel .xlsx files.
• xlwings - A BSD-licensed library that makes it easy to call Python from Excel and vice versa.
• PyPDF2 - A library capable of splitting, merging and transforming PDF pages.
• Python-Markdown - A Python implementation of John Gruber’s Markdown.

Static Site Generator

• nikola - A static website and blog generator.
• pelican - Static site generator that supports Markdown and reST syntax.

Task Queues

• daramatiq - A fast and reliable background task processing library for Python 3.
• huey - Little multi-threaded task queue.
• rq - Simple job queues for Python.